Clinical trials

View the clinical trials and research studies currently recruiting at the Jreissati Family Pancreatic Centre at Epworth.

For further information:

Phone: 03 9426 8880
Email: [email protected]

Current clinical trials

The Jreissati Family Pancreatic Centre at Epworth runs research studies and clinical trials covering every phase of patient diagnosis, treatment and care. The goal is to improve patient outcomes and quality of life for patients with pancreatic cancer.

Clinical trials are vital if we are to improve the survival rate for patients with pancreatic cancer. But what are they?

Need help?

Talk to our pancreatic nurse coordinator

Your pancreatic nurse coordinator will be your first point of contact during your treatment journey at Epworth. They will be able to provide answers to any questions that your or your family may have.

Request form

Request for support for a clinical research study

GP referral

Get referred

Once referred to the Jreissati Family Pancreatic Centre at Epworth, you will have an appointment to see one of our experienced specialists within 72 hours.

Clinical research is vital to improving outcomes for patients with pancreatic cancer. These research studies can be observational studies that involve collecting data on a disease's trajectory to better understand it. They can also be interventional to determine whether an experimental treatment is safe and effective. The main goal of clinical trials is to see if discoveries made during the research phase are better than current treatment options.

For clinical trials, volunteer participation is essential. Results from trials will help determine if new treatments for pancreatic cancer work and if there are side effects. They're also an effective way for patients to gain access to the latest treatment options. Participation leads to advances in research, better treatments, and better patient outcomes.

When deciding if you want to take part in a clinical trial, you need to be aware of what the trial involves. You should also seek advice from your specialist before taking part. At Epworth, there are a number of clinical studies that are open to people with pancreatic cancer and are listed below.

Current clinical trials and special access schemes

Listing updated: 8 February 2022

Diagnosis; Line	Trial ID and Status	Study Title	Locations	Contact
Metastatic pancreatic cancer (Stage IV) 1st and 2nd line	NCT04481009 Recruiting	YH003004 A phase II, multi-center, open-label study to evaluate the safety and efficacy of YH003 in combination with Toripalimab (anti-PD-1 mAb) in patients with unresectable/metastatic melanoma and pancreatic ductal adenocarcinoma (PDAC)	Epworth Freemasons Epworth Richmond	A/Prof Sumitra Ananda
Resectable pancreatic cancer (Stage I-II) 1st line	ACTRN12618000335291 Recruiting	DYNAMIC-Pancreas Circulating Tumour DNA Analysis Informing Adjuvant Chemotherapy in Early Stage Pancreatic Cancer: A Multicentre Randomised Study.	Epworth Freemasons Epworth Richmond	Dr Ross Jennens
Unresectable locally advanced pancreatic cancer (Stage III) Neo-adj	NCT03899636 Recruiting	DIRECT-InspIRE A Multicentre, Open-label, Innovation Study in Pancreatic Cancer Utilising the NanoKnife® System for Irreversible Electroporation (IRE) in Unresectable Stage 3 Pancreatic Adenocarcinoma	Epworth Freemasons	Mr Brett Knowles
Metastatic pancreatic cancer (Stage IV) 1st line	ACTRN12621001290886 Recruiting	ASCEND A randomised, double-blinded phase II study of gemcitabine and nab‐paclitaxel with CEND‐1 or placebo in patients with untreated metastatic pancreatic ductal adenocarcinoma	Epworth Freemasons Epworth Richmond	Dr Ross Jennens
Unresectable locally advanced pancreatic cancer (Stage III)	Special access scheme Taking referrals	OncoSil Epworth is an accredited OncoSil treatment facility	Epworth Richmond	A/Prof Andrew Metz Dr Peter Tagkalidis

Current research studies

These studies may ask participants for permission to store their cancer sample, or take part in non-treatment research. Please get in touch using the online form, email or phone listed on the contact us page to take part in advancing research.

Diagnosis	Project ID and Status	Study Details	Locations	Contact
Individuals at high risk of developing pancreatic cancer (based on demographics and family history)	EH2021-666 Recruiting	APCSP The Australian Pancreatic Cancer Screening Program: Screening for pancreatic cancer in high risk individuals	All Epworth sites	A/Prof Andrew Metz
Suspected diagnosis of pancreatic cancer or cholangiocarcinoma	EH689-15 Recruiting	VPCB The Victorian Pancreatic Cancer Biobank	Epworth Richmond	Dr Peter Tagkalidis
Suspected diagnosis of pancreatic or colorectal cancer	EH2019-481 Recruiting	Organoid Biobank Establishing biobanks of colorectal and pancreatic cancer models for the pursuit of personalised therapies	Epworth Richmond	Mr Brett Knowles
Pancreatic cancer	EH2021-694 Recruiting	EU-ME-PC The Endoscopic Ultrasound Molecular Evaluation of Pancreatic Cancer (EU-ME-PC): A Prospective Multicentre Cohort Trial	All Epworth sites	Dr Allan Zimet
Pancreatic cancer	Recruiting	MoST Molecular Screening and Therapeutics program	All Epworth sites	A/Prof Andrew Metz
Unresectable pancreatic cancer	EH2020-661 Recruiting	OSCILLATE An Observational Study following Circulating tumour DNA during multi-Agent Therapy in PDAC (OSCILLATE): a hypothesis-generating, prospective cohort study	Epworth Freemasons Epworth Richmond Epworth Eastern	Dr Allan Zimet
Primary carer of patient with pancreatic cancer	EH2021-729 Recruiting	PRoCESS Pancreatic Cancer Relatives Counselling and Education Support Service trial. Assessing the effect of nurse-led counselling on participant-reported outcomes and use of medical services.	All Epworth sites	A/Prof Andrew Metz
Newly diagnosed pancreatic cancer	New study Recruiting	PATHWAYS Pancreatic cancer pathways to diagnosis	All Epworth sites	A/Prof Andrew Metz

Databases and registries

These projects ask participants for permission to record treatment data to build better knowledge of pancreatic cancer care. Please get in touch using the online form, email or phone details on the contact us page if you see you or your patient’s diagnosis listed below.

Diagnosis	Project ID and Status	Study Details	Locations	Contact
Newly diagnosed upper GI cancer	EH2017-227 Recruiting	UGICR Upper Gastrointestinal Cancer Registry	Epworth Freemasons Epworth Richmond Epworth Eastern	Mr Brett Knowles
Newly diagnosed pancreatic cancer	ACTRN12617001474347 Recruiting	PURPLE Pancreatic cancer: Understanding Routine Practice and Lifting End Results. A Prospective Pancreatic Cancer Clinical Registry	Epworth Freemasons Epworth Richmond Epworth Eastern	A/Prof Rachel Wong
Intraductal papillary mucinous neoplasm (PPMN)	EH2021-731 Recruiting	IPMN IPMN Database – A tool to predict pancreatic cancer	Epworth Eastern	A/Prof Andrew Metz
Pancreatic cancer	EH2021-768 New study Recruiting	PAN-ExPERT Pancreatic enzyme replacement therapy in pancreatic cancer: An implementation strategy	Epworth Richmond	Mr Mark Cullinan
Pancreatic or oesophageal cancer	Recruiting	PROpatient PROpatient - A registry-based randomised controlled trial (RRCT) of symptom monitoring, using patient-reported outcomes	All Epworth sites	Mr Brett Knowles

Phone: 03 9426 8880
Email: [email protected]